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We also found that several ribosome-/tumor-related genes were particularly actively expressed even in 8-cell preimplantation embryos, and persistent hyperactivation of ribosome biogenesis could play essential roles in the initiation and progression of cancers in IVF-derived offspring

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As detected by JC-1 staining combined with flow cytometry, the PLB-treated group showed a significant enhancement of MMP, reflecting an improvement in mitochondrial function, but YTHDF1 overexpression significantly reduced MMP (Fig