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aegypti , CYP6Z8 plays a pivotal role in pyrethroid clearance via carboxyesterase-mediated hydrolysis that generates 3-phenoxybenzyl alcohol (PBAlc) and 3-phenoxybenzaldehyde (PBAld), and finally 3-phenoxybenzoic acid (PBAcid), all with lower toxicity to the mosquitoes as compared with intact pyrethroids [105, 108, 109]