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Liraglutide Liraglutide, an analog of human GLP- 1, is given once daily by subcutaneous injection and is resistant to the inactivation by dipeptidyl peptidase- 4 (DPP- 4) [91]

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In the Phase 2 obesity trial it produced about 24% weight loss at 12 mg over 48 weeks, the most of any drug in the class, and it cut liver fat by 86% in the people who started with fatty liver. In the 80-week Phase 3 obesity trial of 2,300 adults with an average BMI of 40, 12 mg produced 28% weight loss and 9 mg reached 26%

In preclinical models, glucagon agonism has been associated with increased energy expenditure and hepatic lipid mobilization