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The impact of energy deprivation on the signaling pathways of erythrocytes was later disclosed in a mechanistic study: here, the authors demonstrated that removal of extracellular glucose and blockade of glycolysis by 2-deoxyglucose leads to fast depletion of cellular ATP

Practical considerations for HFRWho to prescribe HFR: indications and clinical objectives Although we can indicate HFR in any type of patient, as it is considered a superior technique in terms of biocompatibility, uremic toxin clearance and preservation of nutritional status, there are specific circumstances and patients with specific needs in which this technique would be especially indicated and which must be taken into account in order to prescribe the most individualized dialysis therapy possible, centered on the patient (Table 4)