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Over these three decades, a decrease in the prevalence of genotype 1b was observed, as well as an increase in the prevalence of genotypes 1a, 3 and 4, as reported extensively in Europe.12,13,2430,3436,40 Our study tentatively suggests that the significant increase in the prevalence of genotype 3 might have taken place mainly in the period 19952005, while the increasing presence of genotypes 1a and 4 is more recent

The S in 3S refers to the series connection, while the number 3 indicates the number of cells

MHT confirms that to the best of his knowledge none of the above funding sources were involved in the preparation of this paper