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NAC may be supportive in APD by: Helping replenish glutathione, which plays a role in regulating immune responses Reducing oxidative stress that can worsen mast cell activation and inflammation Supporting overall inflammatory balance, particularly during hormonally driven immune flares Some research also suggests NAC may influence mast cellmediated pathways indirectly 13 , which may be relevant in conditions where histamine release contributes to symptoms
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The concentration of GSH in the mitochondrial compartment is more important for cell survival than the GSH found in the cytosol
Nevertheless, dietary supplements for DS still receive a lot of attention from parents, which leads to efforts of scientists to define the possible benefits of dietary supplements for people with DS-based on scientifically based knowledge
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