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Murine studies published in Cell used 5mg/kg as a threshold dose for measurable senescent cell reduction in naturally aged mice, with 10mg/kg producing maximal effect without off-target toxicity

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Prevention of cardiorenal complications and beyond With the improvement in the management of cardiovascular risk factors, a progressive decline in the annual incidence rate of cardiovascular morbidity and mortality has been observed in both the general population and the diabetic population over the past decades

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