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Unlike its established role in CD95-mediated apoptosis of nucleated cells, ceramide promotes eryptosis primarily by enhancing Ca 2+ sensitivity rather than directly facilitating Ca 2+ entry (Gulbins et al., 1995)

We thus decided to start our investigation by replacing four consecutive amino acids (X 4 ) with three consecutive ureido residues (X u 3 ) based on our model, suggesting that this combination gives the best overlaps of the terminal atoms (Fig

Fagundes DS, Grasa L, Gonzalo S, et al

patients with these features should be strongly suspected of having MC4R -deficient obesity, and genetic evaluation should be considered