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Patients entered a 2-week placebo run-in period on MDI insulin with or without metformin background therapy

moreover, it increases the expression of vascular endothelial growth factor, which is a potent angiogenic factor, whereas tumor necrosis factor-, interleukin-6, and nuclear factor kappa B expression are inhibited, which benefits the healing of diabetic wounds (Qiang et al., 2017

Diabetes Care (2010) 33:16079

Studies have documented its capacity to stimulate collagen and glycosaminoglycan synthesis, accelerate wound healing, promote angiogenesis, exert antioxidant and anti-inflammatory effects, and modulate the expression of genes involved in tissue repair and regeneration