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5.3 Microbial-ferroptosis interaction as a therapeutic target of IBD Collectively, accumulating studies suggest that the microbiotametaboliteferroptosis axis contributes to IBD pathogenesis ( Table 1 ) (132)

These findings emphasize that targeted antagonism of NMDA receptor signalling lowers body weight independently of MC4R, indicating that this preclinical drug candidate might not only be effective in treating polygenic obesity but also holds potential as an effective weight loss strategy for patients with loss-of-function mutations in MC4R , the most common form of monogenic obesity 32

While generally safe, individuals should consult their healthcare provider before starting IM injections, especially if they have pre-existing health conditions or allergies

It serves an endocrine function, providing IGF1R activation to peripheral tissues distant from the production site