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These canonical functions positioned DHODH primarily as a metabolic enzyme critical for nucleotide biosynthesis and cellular proliferation, before its more recent identification as a mitochondria-specific ferroptosis suppressor in select cancer contexts

L-Glutathione Reduced, often simply called reduced glutathione (GSH), is the biologically active form of glutathionea tripeptide composed of L-glutamic acid, L-cysteine, and glycine

ACSL4 is the key enzyme catalyzing the activation of long-chain fatty acids in ferroptosis, and its aberrant expression is closely associated with a number of biological responses, including steroidogenesis, inflammatory responses, cell death, and immune activation responses (54)