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In clinical trials of oral GLP1 medications, digestive symptoms were the most frequently reported side effects, occurring at rates similar to those seen with injections

Several clinical trials implemented a combination of semaglutide treatments with sulfonylurea, sitagliptin, basal insulin, metformin, or other antidiabetic drugs (Table 3)

Conclusion GLP-1 receptor agonists have emerged as essential tools in cardiovascular medicine, transcending their original purpose as antihyperglycemic agents

Exenatide did not work in cocaine use disorder, but it did reduce drinking in obese patients with alcohol use disorder (Klausen MK et al, JCI Insight 2022;7(19):e159863)