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Notably, these effective concentrations were 16,000-80,000,000 times lower than concentrations of melatonin required for comparable effects, suggesting highly potent regulatory mechanisms rather than simple antioxidant activity

3 Urolithin A and sleep: current evidence For this mini-review, we utilized a hypothesis-based scoping review method where we conducted a search on PubMed, Scopus and Ovid utilizing the terms urolithin A and sleep, urolithin A and circadian, and urolithin A and serotonin or tryptophan. Our inclusion criteria were (1) original research articles, (2) published in English, (3) utilizing isolated urolithin A (no mixtures or parent polyphenols) and (4) including at least one outcome relevant to sleep or sleep-related biological mechanisms, with no constraints on publication date

Khatri and Pandit 2022), the cultivation and processing stages of Spirulina could also represent potential environmental hotspots