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1,18 Since ten years ago, a series of therapeutic agents and combinatorial approaches have been approved by FDA, including immunotherapy (single-agent ipilimumab, nivolumab, pembrolizumab, and combination of ipilimumab and nivolumab), targeted therapy (single-agent vemurafenib and dabrafenib, combinations of dabrafenib plus trametinib, vemurafenib plus cobimetinib, and encorafenib plus binimetinib) as well as one intralesional modified oncolytic herpes virus talimogene laherparepvec (T-VEC) (Fig

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In triple-negative breast cancer (TNBC), mutant p53 induces nonclassical apoptosis via aberrant interaction with MDM2, independent of wild-type p53 [49]