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Necrosis, like apoptosis, can be triggered by various factors, including cellular stress (especially oxidative stress), ATP depletion, calpain activation, and even death receptor activation (TNF- and Fas) [34]

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This innovative nanosystem encapsulates DNAzymes, a single-stranded catalytic DNA molecule renowned for its diverse biological functionalities, including gene silencing, the selective cleavage of specific mRNA sequences, and the facilitation of various chemical transformations through catalytic activity 38,39,40

Results showed the mix was highly effective in this challenging population, producing average weight loss of 20-22% over 68 weeks compared to 12-14% with semaglutide alone