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In a pediatric clinical trial, 2.3% of patients treated with WEGOVY versus 1.5% of patients who received placebo discontinued treatment as a result of gastrointestinal adverse reactions

239 Although glia can be beneficial in clearing misfolded aggregates in normal physiological conditions, this mechanism may have negative consequences in disease

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This multi-receptor interaction profile differentiates GLP-3R from earlier peptide constructs that primarily targeted single-pathway or dual-pathway receptor activity