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The AKT/mTOR hyperactivation in these organoids suggests that mTOR inhibitors (e.g., rapamycin analogs) may ameliorate synaptic imbalances, warranting clinical exploration in ASD subtypes with CNTNAP2 mutations

These findings elucidate the underlying mechanisms by which formulations derived from crude extracts, as previously examined [33], might exhibit inadequate efficacy due to chemical antagonism or suboptimal concentrations of active metabolites

katsumadai was found to possess an anti-inflammatory effect by its ability to decrease paw edema after carrageenan administration