Classification of these pathways according to the involved pathological process revealed a broad division into inflammation-related pathways (chemokine signaling, cytokine-cytokine receptor interaction, MAPK signaling, Toll-like receptor signaling, NOD-like receptor signaling, NF-B signaling, etc.), metabolism-related pathways (phagosome, PI3K-AKT signaling, etc.), and fibrosis-related pathways (ECM-receptor interaction) (Figure 7C)
Further studies are required to determine to extent to which the neuroprotective effects of Nrf2 activation involve the prevention of ferroptosis
12-14 Moreover, SOD-1 activity has been found to be increased by about 50% in all tissues of patients with DS
Gatto C, Milanick M (2009) Red blood cell Na pump: insights from species differences