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Galectin-3 plays an important pro-inflammatory role in the induction phase of acute colitis by promoting activation of NLRP3 inflammasome and production of IL-1 in macrophages

On the other hand, some data on chronic administration of long acting GLP1RAs have established that deceleration of gastric emptying does continue albeit less compared to short-acting GLP1RAs

In 2022, the FDA also approved Wegovy as a treatment for teenagers with obesity