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Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )

Restoring NAD+ levels in animal models has reversed multiple aging biomarkers

These include the competing effects of the formation of cobalamin-like molecules in our body (the so-called cobalamin analogues or pseudo-cobalamins), which may impair the proper action of the good cobalamin

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