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Kubo K et al

Active cancer or history of malignancy Pregnancy or breastfeeding Known peptide allergies Athletes subject to anti-doping testing (WADA prohibited) Raynauds disease or phenomenon Cold urticaria (hives from cold) Uncontrolled hypertension Peripheral vascular disease Open wounds (for local application) Pregnancy Cardiovascular conditions Diabetes (especially with neuropathy) Current infections Immunosuppression Blood clotting disorders Quality control issues represent perhaps the greatest practical risk with BPC-157

And the third, involving two healthy people, simply showed that BPC-157 was well tolerated, with no adverse effects

Ibuprofen Given for 4 weeks, ibuprofen severely disturbed both lower esophageal sphincter and pyloric sphincter