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however, loss of genes in two or more pathways cause most GSCs to fail to differentiate/enter meiosis and results in a germline tumor of mostly undifferentiated cells

196 These findings suggest that CTSD contributes to AP progression not only through its actions in acinar cells but also via its role in inflammatory cells

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For example, an athlete returns to training and preparing for competitions after a long break, begins a new and difficult training cycle, or an athlete is exposed to such stresses as being on high ground (for example, in mountains), in a place where smog accumulates, or in very hot or cold climatic conditions