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14 Early research on the therapeutic potential of GLP-1 was directed towards glucose regulation in diabetes but was extended, through concurrent observations of body weight lowering to obesity management

The important result comes from studies that compare two drugs together: taking Cagrilintide (2.4 mg) and Semaglutide (2.4 mg) once a week leads to about 21% weight loss after 32 weeks, showing that the two drugs work well together

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Growth hormone production peaks in adolescence and declines through adulthood, and IGF-1, the downstream messenger that drives muscle protein synthesis and tissue repair, declines along with it