iih glp 1 The effect of GLP-1 agonist on idiopathic intracranial hypertension: a systematic review and meta-analysis glp 1 receptor agonists in

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TL;DR: In a large sample of US Veterans, GLP-1 drugs were associated with reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimers disease and dementia), coagulation disorders, cardiometabolic disorders, infectious illnesses and several respiratory conditions, but increased risk of gastrointestinal issues, hypotension (low blood pressure), and some kidney-related conditions

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It reduces the cohesion of corneocytes at the junction of the stratum corneum and granulosum, which leads to thinning of the epidermis with continued use