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Bioact Mater Bioact Mater

Age-dependent decline in -cell proliferation restricts the capacity of -cell regeneration in mice

Should we be worried

Unlike the potent TGR5 agonists, DCA and LCA, we could not detect any effects of TMCA on cAMP levels in the STC-1 cells, NCI-H716 cells, and mouse intestinal organoids, suggesting that the increased ileal TMCA observed in the mice after T3 treatment might not act via TGR5-mediated pathway