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A small number of users may experience gastrointestinal effects so severe that they need to stop taking the medication

We hypothesized that patients with stable schizophrenia would exhibit a reduction in glutathione, glutamate, and/or glutamine in the cerebral cortex, consistent with a post-inflammatory response, and that this reduction would be most marked in patients with residual schizophrenia, in whom an early stage with positive psychotic symptoms has progressed to a late stage characterized by long-term negative symptoms and impairments

Free Radic Biol Med 129:454462

By improving both stress hormones and sleep architecture, saffron helps promote a favorable environment for weight loss