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Retatrutide and Appetite Regulation Through stimulation of GLP-1 and GIP receptors, Reta appears to influence satiety signaling in the hypothalamus, which may contribute to reduced food intake in preclinical models

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The CANVAS (Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes) trial revealed lower risk for death from cardiovascular causes, nonfatal myocardial infarction, and nonfatal stroke in patients with established type 2 diabetes and cardiovascular disease treated with canagliflozin in comparison to placebo

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