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Antihypertensive drugs work via different pathwaysACE inhibitors block angiotensin II, beta-blockers reduce heart rate and contractility, and calcium channel blockers relax vascular smooth muscle

In an animal model, semaglutide demonstrated neuroprotective effects and improved cognitive function by inhibiting the release of inflammatory cytokines mediated by the NLRP3 inflammasome, a protein involved in regulating the innate immune system and inflammatory responses

Additionally, recent studies mapping specific inputs to PPG neurons demonstrated that only subgroups of PPG neurons received individual inputs (Brierley et al., 2021