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In clinical practice, a B1-B6-B12 injection may be considered when oral therapy is insufficient or not feasible, such as in malabsorption, severe deficiency, or when accelerated replenishment is desired under medical supervision

Bostom AG, Roubenoff R, Dellaripa P, Nadeau MR, Sutherland P, Wilson PWF, Jacques PF, Selhub J, and Rosenberg IH (1995b)

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It has been observed that PARIS (ZNF746) is a transcriptional repressor of PGC-1 and NRF1, as well as a common substrate for PINK1 and parkin