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A nested case-control study within the Singapore Chinese Health Study demonstrated a significant 57% reduction in colon cancer risk among high consumers of dietary isothiocyanates (ITCs) who carried the double null genotype, suggesting that compromised GST activity enhances the protective effect of ITCs like SFN ( By integrating the roles of the gut microbiome and host genetics, it becomes clear that the biological activity of SFN is not solely a function of the ingested dose

10.3390/md9030447 Mar