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A recent meta-analysis of all the double-blind, placebo-controlled, randomized clinical trials of N-acetylcysteine as adjunctive therapy in bipolar depression confirmed its superiority over placebo in reducing depressive symptoms with a moderate effect size (95% confidence interval 0.060.84) [61]

This concept underscores the necessity for dynamic and precisely controlled redox modulation strategies capable of adapting to different pathological phases

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