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We set out to develop biochemical biomarkers of target engagement (a direct measure of drug action) to measure the effects of therapies targeting oxidative stress, including edaravone and nuclear factor erythroid 2-related factor 2 (NRF2) activators [3], which show promise as disease-modifying agents for neurodegenerative diseases
Subcutaneous medications are not intended for injection into the muscle and, if administered into muscle, may result in bleeding into the muscle tissue
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